產品編號 | bs-19103R-HRP |
英文名稱 | Rabbit Anti-Munc 13-4/HRP Conjugated antibody |
中文名稱 | 辣根過氧化物酶標記的UNC13D蛋白抗體 |
別 名 | FHL 3; FHL3; FLJ00067; HLH 3; HLH3; HPLH 3; HPLH3; Jinx; Munc13 4; Munc13-4; Protein unc 13 homolog D; Protein unc-13 homolog D; UN13D_HUMAN; Unc 13 homolog D; UNC 13D; Unc-13 homolog D (C. elegans); Unc13 homolog D (C elegans); Unc13 homolog D; UNC13, C. elegans, homolog of, D; UNC13D; Unc13h4 |
規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
說 明 書 | 100ul |
研究領域 | 細胞生物 免疫學 t-淋巴細胞 |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應 | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rhesus monkey) |
產品應用 | WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 123kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human Munc 13- |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產品介紹 |
background: This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder. [provided by RefSeq, Jul 2008] Function: Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. Subcellular Location: Cytoplasm. Membrane. Late endosome. Recycling endosome. Lysosome. Colocalizes with cytotoxic granules at the plasma membrane. Localizes to endosomal exocytic vesicles. Tissue Specificity: Expressed at high levels in spleen, thymus and leukocytes. Also expressed in lung and placenta, and at very low levels in brain, heart, skeletal muscle and kidney. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells. DISEASE: Defects in UNC13D are the cause of hemophagocytic lymphohistiocytosis familial type 3 (FHL3) [MIM:608898]; also known as HPLH3. Familial hemophagocytic lymphohistiocytosis (FHL) is a genetically heterogeneous, rare autosomal recessive disorder. It is characterized by immune dysregulation with hypercytokinemia and defective natural killer cell function. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hypofibrinogenemia, and neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits, and ataxia. Hemophagocytosis is a prominent feature of the disease, and a non-malignant infiltration of macrophages and activated T lymphocytes in lymph nodes, spleen, and other organs is also found. Similarity: Belongs to the unc-13 family. Contains 2 C2 domains. Contains 1 MHD1 (MUNC13 homology domain 1) domain. Contains 1 MHD2 (MUNC13 homology domain 2) domain. Database links: Entrez Gene: 201294 Human Entrez Gene: 70450 Mouse Entrez Gene: 704431 Rhesus monkey Omim: 608897 Human SwissProt: Q70J99 Human SwissProt: B2RUP2 Mouse Unigene: 41045 Human Unigene: 259460 Mouse Unigene: 198919 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
1、抗體溶解方法 | |
2、抗體修復方式 | |
3、常用試劑的配制 | |
4、免疫組化操作步驟 | |
5、免疫組化問題解答 | |
6、Western Blotting 操作步驟 | |
7、Western Blotting 問題解答 | |
8、關于肽鏈的設計 | |
9、多肽的溶解與保存 | |
10、酶標抗體效價測定程序 | |
| 国产免费AV片在线无码免费看 | 少妇搡BBBB搡BBB搡视频一级 | 丰满人妻中伦妇伦精品久久 | 国产欧美一区二区三区特黄手机版 | 无码人妻一区二区三区线花季传件 | 国产亚洲精品成人a v久久网站 | 国产精品免费一区二区三区在线观看 | A级毛片试看120分钟 | 精品无码秘 人妻一区二区 1024人妻一区二区三区 | 激情婬乱A片吸吸视频 | 亚洲中文字幕一区 | 又粗又大又黄A片免费看樱花 | 成人女同 AV在线观看 | 又大又粗又黄又免费观看 | 亚洲AV无码成人精品区国产 | 欧–美–性–交–黄–片 | 少妇BBBBB揉BBBBB揉 | 国产无码精品一区二区 | 高跟肉丝丝袜呻吟啪啪网站AV | 欧美在线精品成人网站 | 国产熟妇肥臀多毛BBW | 四川丰满少妇被弄到高潮 | 国产精品人妻一期二期三期四期 | 污网站高清无码在线观看 | 中文字幕一区二区av | 黄网站永久免费在线观看 | 蜜桃人妻无码AV天堂三区 | 又大又长又粗一区二区 | 中文字幕av在线播放 | 东北老熟女91对白真实 | 在线观看黄色视频免费 | 91嫩草国产婷婷二区三区 | 欧美特黄色一级视频大片 | 日本少妇做爰一区二区 | 九一久久亚洲欧美精品午睡沙发 | 亚洲无码电影在线观看 | 国产女人永久免费裸体 | 亚洲精品国产AV | 日韩欧美高清在线观看 | 国产成人精品一区 |