產(chǎn)品編號(hào) | bs-18782R-Cy5 |
英文名稱(chēng) | Rabbit Anti-Mel18/Cy5 Conjugated antibody |
中文名稱(chēng) | Cy5標(biāo)記的DNA結(jié)合蛋白Mel18抗體 |
別 名 | DNA binding protein Mel 18; DNA-binding protein Mel-18; Mel 18; MEL-18; MGC10545; PCGF 2; PCGF2; PCGF2_HUMAN; Polycomb group ring finger 2; Polycomb group RING finger protein 2; Ring finger protein 110; RNF 110; RNF110; Zinc finger protein 144; ZNF 144; ZNF144. |
規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢(xún)價(jià) |
說(shuō) 明 書(shū) | 100ul |
研究領(lǐng)域 | 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 表觀(guān)遺傳學(xué) 泛素 |
抗體來(lái)源 | Rabbit |
克隆類(lèi)型 | Polyclonal |
交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Chimpanzee, Macaque Monkey) |
產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 38kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human Mel18 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. [provided by RefSeq, Jul 2008] Subunit: Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Subcellular Location: Nucleus. Tissue Specificity: Detected in all tissues examined with high expression found in placenta lung and kidney and low expression, in liver, pancreas and skeletal muscle. Post-translational modifications: Phosphorylated. Homodimer formation is regulated by phosphorylation state with unphosphorylated protein forming homodimers. Similarity: Contains 1 RING-type zinc finger. Database links: Entrez Gene: 7703 Human Entrez Gene: 22658 Mouse Omim: 600346 Human SwissProt: P35227 Human SwissProt: P23798 Mouse Unigene: 371617 Human Unigene: 713595 Human Unigene: 2418 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 国产精品欲AV蜜臀 | 国产小视频在线播放 | 免费性爱视频手机观看 | 亚洲AV无码专区一级婬片毛片 | 強暴強姦AV正片在线 | 国产裸体舞一区二区三区婚闹 | 精品少妇V888AV | 一级少妇精品内射自慰久久久久 | 三级片国产无遮挡白浆 | 久久综合精品成人电影 | 亚洲人妻一区二区三区 | 少妇被黑人到高潮喷白浆 | 波多野结衣无码久久无码 | 国产成人无码精品久久 | 91人人妻人人澡人人爽国产网址 | 亚洲小说区图片区 | 国产精品久久久精品影视 | 亚洲精品毛A片久久久爽 | 免费观看永久视频18 | 久久欧美国产伦子伦精品 | 免费看A片秘 免费麻豆 | 搡老女人老妇女aaa一区麻豆 | 国产寡妇婬乱a毛片视频中文 | 中文字幕一区二区在线观看 | 亚洲国精一区二区无码蜜桃 | 国产做受 高潮久久 | 精品亚洲自慰无码喷奶水 | 国产欧美精品一区二区 | 国产后入欧美学生妹视频 | 狂揉小泬少妇精品无码 | 北条麻纪在线观看AⅤ | 极品主播被你爽到高潮了 | 青青草无码成人AV片 | 色婷婷日韩精品一区二区三区 | 日逼动图120秒免费试看 | 人人妻人人躁人人爽 | 成人午夜电影在线播放 | 亚洲精品无码成人A片在线沈先生 | 真一人一性一交一黄一片 | 日本熟女黄色视频下载 |