强伦轩一级A片在线观看,中文字幕乱码人妻二区三区,鲁鲁狠狠狠7777一区二区,西西4444www无码精品
掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
91视频免费观看,国产与子敌伦一级A片,秘 亚洲国产精品成人网站
Rabbit Anti-ZFYVE27/PE-Cy7 Conjugated antibody (bs-11777R-PE-Cy7)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-11777R-PE-Cy7
英文名稱 Rabbit Anti-ZFYVE27/PE-Cy7 Conjugated antibody
中文名稱 PE-Cy7標(biāo)記的鋅指FYVE結(jié)構(gòu)域蛋白27抗體
別    名 Protrudin; RP11 459F3.2; SPG33; ZFY27_HUMAN; ZFYVE27; zinc finger FYVE domain containing 27; Zinc finger FYVE domain containing protein 27; Zinc finger FYVE domain-containing protein 27.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 神經(jīng)生物學(xué)  鋅指蛋白  細(xì)胞膜蛋白  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat,  (predicted: Dog, Cow, Rabbit, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 46kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ZFYVE27
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Zinc finger FYVE domain-containing protein 27 (ZFYVE27), also known as SPG33, is a 411 amino acid member of the FYVE-finger family of proteins. The FYVE domain is a cysteine-rich domain of about 70 amino acids that plays a role in the endosomal localization of the FYVE-finger proteins, and a majority of these proteins serve as regulators of endocytic membrane trafficking. ZFYVE27, a multi-pass membrane protein, is an endosomal protein that binds to Spastin, a protein that is primarily involved in microtubule dynamics and severing, vesicular trafficking and endosomal trafficking. Mutations in the gene encoding ZFTVE27 affect neuronal intracellular trafficking in the corticospinal tract and are thought to lead to hereditary spastic paraplegia (HSP), a neurodegenerative disorder, characterized by progressive paralysis of the legs, which is caused by impaired axonal transport. Five isoforms of ZFYVE27 exist as a result of alternative splicing events.

Function:
Functions as an upstream inhibitor of RAB11, regulating directional protein transport to the forming neurites. Involved in nerve growth factor-induced neurite formation. May have a more general role in cell projections formation.

Subcellular Location:
Recycling endosome membrane. Endoplasmic reticulum membrane. Cell projection > growth cone membrane. Cell membrane. Localizes at both dendrites and axons.

Post-translational modifications:
Phosphorylated. Phosphorylation is induced by NGF through the MAPK/ERK pathway and modulates interaction with RAB11A.

DISEASE:
Defects in ZFYVE27 are the cause of spastic paraplegia autosomal dominant type 33 (SPG33) [MIM:610244]. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Note=According to PubMed:18606302, the properties of the variant Val-191 and its frequency in some populations raise doubts on the implication of that gene in the disease.

Similarity:
Contains 1 FYVE-type zinc finger.

Database links:

Entrez Gene: 486825 Dog

Entrez Gene: 118813 Human

Entrez Gene: 319740 Mouse

Entrez Gene: 309376 Rat

Omim: 610243 Human

SwissProt: Q5T4F4 Human

SwissProt: Q3TXX3 Mouse

SwissProt: Q6P7B7 Rat

Unigene: 523194 Human

Unigene: 287359 Mouse

Unigene: 470071 Mouse

Unigene: 99939 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 m.nmgps.com 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
欧亚精品乱码久久久久久 | 嫩草影院A片久久精品91 | 亚洲国产成人精品无码区6080 | 成人A片无码永久免费第三集 | 久久久久久久君君jjjj | 一本色道**综合**人妻 | 欧美一级搡BBBB搡BBBB | 4444www大胆无码视频 | 特级特黄AAAAAAAA片 | 亚洲喷水自慰国产高潮 | 免费无码婬片AAAA片蜜桃 | 特一级一性一交一视频 | 国产精品人妻久久久久厨房 | 国产精品成人AAAA网站女吊丝 | 东北女人无套内谢毛片 | 国产又猛又粗又硬又色的视频 | 性欧美激情小妇人猛交 | 色婷婷AV一区二区三区婷婷五月 | 日本人做爰毛片免费播 | 欧美最猛黑A片黑人猛交蜜桃视频 | 91精品久久久久久久99蜜桃 | 国产欧美大屁股喷水无码视频 | 91久久精品一区二区三 | 亚洲精品一区二区三区四区高清 | 久久久久久久久久久久久久动漫 | 疯狂欧美大伦交的历史 | 亚洲大片免费观看 | 在线观看视频一区二区禁 | 狂野欧美性猛伦XXXX | 美女被内射内径乱喷 | 日本吞精合集手机在线观看 | 蜜桃aⅴ色欲A片无码精品接吻 | 久久99精品国产自在现线 | 国产在线拍揄自揄拍无码视频 | 久密桃精品AV妻菠萝9 | 午夜国产三级理伦片 | 香港三日本三级少妇66 | 岳的大肥坹一级A片无码视频 | 丰满人妻的婬乱生活2 | 一级毛片久久久久久久女人18 | 成人无码www樱桃影视 |