强伦轩一级A片在线观看,中文字幕乱码人妻二区三区,鲁鲁狠狠狠7777一区二区,西西4444www无码精品
掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
日本无码一区二区三三,日本无码熟人中文字幕,韩国一区二区三区
Rabbit Anti-phospho-Dnmt1(Tyr399)/PE-Cy3 Conjugated antibody (bs-5296R-PE-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-5296R-PE-Cy3
英文名稱 Rabbit Anti-phospho-Dnmt1(Tyr399)/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標(biāo)記的磷酸化DNA甲基轉(zhuǎn)移酶1抗體
別    名 Dnmt1(phospho Y399); Dnmt1 (phospho Tyr399); p-Dnmt1 (Tyr399); AIM; CXXC finger protein 9; CXXC-type zinc finger protein 9; CXXC9; DNA (cytosine 5 ) methyltransferase 1; DNA (cytosine-5)-methyltransferase 1; DNA methyltransferase 1; DNA methyltransferase HsaI; DNA methyltransferase M.HsaI.; DNA MTase; DNA MTase HsaI; DNMT 1; DNMT; Dnmt1; Dnmt1; DNMT1_HUMAN; Dnmt1o; FLJ16293; HSN1E; M.HsaI; MCMT; Met1; MGC104992; mMmul; MommeD2.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  免疫學(xué)  細(xì)胞凋亡  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Dog, Pig, Horse, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 178kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Dnmt1 around the phosphorylation site of Tyr399
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].

Function:
Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.

Subunit:
Binds to CSNK1D (By similarity). Homodimer. Interacts with HDAC1 and with PCNA. Forms a complex with DMAP1 and HDAC2, with direct interaction. Forms also a stable complex with E2F1, BB1 and HDAC1. Binds MBD2 and MBD3. Component of complexes containing SUV39H1. Interacts with DNMT3A and DNMT3B. Interacts with the PRC2/EED-EZH2 complex. Interacts with UBC9 and BAZ2A/TIP5.

Subcellular Location:
Nucleus.

Tissue Specificity:
Ubiquitous; highly expressed in fetal tissues, heart, kidney, placenta, peripheral blood mononuclear cells, and expressed at lower levels in spleen, lung, brain, small intestine, colon, liver, and skeletal muscle. Isoform 2 is less expressed than isoform 1.

Post-translational modifications:
Sumoylated; sumoylation increases activity.
Acetylation on multiple lysines, mainly by KAT2B/PCAF, regulates cell cycle G(2)/M transition. Deacetylation of Lys-1349 and Lys-1415 by SIRT1 increases methyltransferase activity.
Phosphorylation of Ser-154 by CDKs is important for enzymatic activity and protein stability. Phosphorylation of Ser-143 by AKT1 prevents methylation by SETD7 therebye increasing DNMT1 stability.
Methylation at Lys-142 by SETD7 promotes DNMT1 proteasomal degradation.

DISEASE:
Defects in DNMT1 are the cause of hereditary sensory neuropathy type 1E (HSN1E) [MIM:614116]. A neurodegenerative disorder characterized by adult onset of progressive peripheral sensory loss associated with progressive hearing impairment and early-onset dementia.

Similarity:
Belongs to the C5-methyltransferase family.
Contains 2 BAH domains.
Contains 1 CXXC-type zinc finger.

Database links:
UniProtKB/Swiss-Prot: P26358.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

DNA甲基轉(zhuǎn)移酶-1在多種腫瘤細(xì)胞中表達(dá)量相當(dāng)高,而在正常成人細(xì)胞中則低表達(dá),因此dnmt1基因的高表達(dá)與腫瘤的發(fā)生有密切的關(guān)系。 dnmt-1 對細(xì)胞周期、增殖及凋亡有一定的的影響。細(xì)胞核表達(dá)。 (isoform CRA_a)為抑制細(xì)胞增殖、促進(jìn)細(xì)胞凋亡,為腫瘤的基因治療提供依據(jù)。
版權(quán)所有 2004-2026 m.nmgps.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
日韩AV电影在线观看 | 国产精品久久久久久久 | 亚洲精品无码你懂的 | 免费无遮挡无码永久在线观看视频 | 久久一级毛片内射人妖 | 女18一成人免费A级毛片 | 在线观看免费观看av | 久久综合师生制服丝袜人妻4k岛国 | 中文字幕乱偷在线影院 | 18禁成人老师免费看入口 | 成人免费视频 国产免费看 ,国产乱人伦无无码视频 | 十八禁网站免费观看 | 成人免费视频 网站 | 国产精品 久久久精品软件 中文字幕在线观看一区二区 | 国产高清一级黄色电影 | 欧美成人精品免费17c | 国产黃色A片三級三級三級四川 | 国产无码电影在线观看 | 黄色成人网站在线观看 | 正在播放长泽梓无码中出 | 极品媚黑91黑人在线播放 | AV不卡一区二区三区 | 精品国产乱码一区二区 | 国产一级a毛一级a看免费软件特色 | 成人无码一级A片播放视频 蜜桃AV网站无码成人一区 | 四川寡妇搡BBB爽爽爽 | 国产一级婬乱片A片AAA图片 | 亚洲精品视频免费看 | 精品人妻一区二区三区影院 | 欧美 a片在线视频 | 又黄又粗又猛国产免费 | 欧美成人一级二级三级视频 | 欧美偷伦无码一区二区 | 性欧美婬妇ⅹXXX视频 | 久产久久精网页版白丝 | 国产精品jizz中国一级片 | 乱子伦熟妇aVvvzhe汁 | 亚洲女子裸体在线观看 | 性感美女在线观看网站 | 99久久久成人国产精品 | 激情小说 激情图片 |