產(chǎn)品編號(hào) | bs-1047R-PE-Cy7 |
英文名稱(chēng) | Rabbit Anti-MyD88/PE-Cy7 Conjugated antibody |
中文名稱(chēng) | PE-Cy7標(biāo)記的髓樣分化蛋白抗體 |
別 名 | myeloid differential protein-88; Myeloid differentiation primary response gene; MYD 88; MYD88D; Myeloid differentiation marker 88; Myeloid differentiation primary response gene 88; Myeloid differentiation primary response gene; Myeloid differentiation primary response protein MyD88; MYD 88; Myd88; MYD88_HUMAN; OTTHUMP00000161718; OTTHUMP00000208595; OTTHUMP00000209058; OTTHUMP00000209059; OTTHUMP00000209060. |
規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢價(jià) |
說(shuō) 明 書(shū) | 100ul |
研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) |
抗體來(lái)源 | Rabbit |
克隆類(lèi)型 | Polyclonal |
交叉反應(yīng) | Human, Mouse, (predicted: Rat, ) |
產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 34kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from mouse MyD88 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]. Function: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine. Subunit: Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains. Interacts with IL18R1 (By similarity). Interacts with BMX, IL1RL1 and IRF7. Interacts with LRRFIP1 and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist. Interacts with FLII. LRRFIP1 and LRRFIP2 compete with FLII for MYD88-binding. Interacts with IRF1. May interact with PIK3AP1 (By similarity). Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and TRAF6; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. Subcellular Location: Cytoplasm. Tissue Specificity: Ubiquitous. DISEASE: Defects in MYD88 are the cause of MYD88 deficiency (MYD88D) [MIM:612260]; also known as recurrent pyogenic bacterial infections due to MYD88 deficiency. Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age. Similarity: Contains 1 death domain. Contains 1 TIR domain. Database links: Entrez Gene: 4615 Human Entrez Gene: 17874 Mouse Omim: 602170 Human SwissProt: Q99836 Human SwissProt: P22366 Mouse Unigene: 82116 Human Unigene: 213003 Mouse Unigene: 37341 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. MyD88是天然免疫中的調(diào)控分子,可能在感染、炎癥、免疫等病理生理過(guò)程中具有更廣泛的生物學(xué)功能, MyD88蛋白是由Toll樣受體介導(dǎo)的先天免疫應(yīng)答反應(yīng)中重要的胞漿接頭蛋白,由它參與構(gòu)成的信號(hào)級(jí)聯(lián)最終引起NF-kB依賴(lài)性信號(hào)通路的活化。 |
| 欧美黑人一级A片免费看 | 污黄网站在线观看视频 | www.xx孟交巴巴 | 丰满人妻被猛烈进入中文字幕 | 性欧美婬妇ⅹXXX视频 | 中文字幕av一区二区三区佐山爱 | 成人做爰www免费看视频网站 | 天天摸天天操国语对白 | 欧美亚洲国产精品久久高清浪潮 | 大黑人狂躁美女大BBBB小说 | 18岁美女污污污网站 | 国产精品伦人视频免费看三丽医院 | 黄色高清免费视频在线观看 | 国产精品一区二区视频 | 北京熟妇槡BBBB槡BBBB一 | 国产一级a毛一级a做免费图 | 午夜视频在线观看视频91 | 一级国产免费av片 | 国产裸体免费无遮挡香港特辑 | chaopeng在线视频公开 | 18j禁羞羞在线 | 亚洲激情视频在线观看 | 国产熟睡乱子伦午夜视频在线 | 麻豆成人传媒AV国产在线 | 国产一区精品在线观看 | 国产伦精品一区二区三区视频女 | 国产精品久久久午夜夜伦鲁鲁 | 特级西西人体444www高清大 | 久久久久亚洲Av无码A片 | 西西人体44www大胆无码 | 清纯白嫩初高中在线播放 | 国产精品久久久久影院老司 | 国产97欧美日韩丝袜自慰 | 免费黄色十八摸在线观看 | 亚洲精品一区二区三区中文字幕 | 少妇做爰免费8级A片 | 97国产精品视频人人做人人爱 | 欧美mv日韩mv| 国产伦精品一区二区三毛 | 无码人妻精品一区二区性活 |