產(chǎn)品編號(hào) | bs-3123R-BF647 |
英文名稱 | Rabbit Anti-Phospho-Cyclin B1 (Ser133)/BF647 Conjugated antibody |
中文名稱 | BF647標(biāo)記的磷酸化周期素B1抗體 |
別 名 | Cyclin B1 (phospho S133); Cyclin B1 (phospho-Ser133); p-Cyclin B1 (S133); p-Cyclin B1 (Ser133); p-Cyclin B1 (phospho S133); CCNB 1; CCNB; CCNB1; CCNB1_HUMAN; G2 mitotic specific cyclin B1; G2/mitotic-specific cyclin-B1. |
規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
說(shuō) 明 書 | 100ul |
產(chǎn)品類型 | 磷酸化抗體 |
研究領(lǐng)域 | 腫瘤 |
抗體來(lái)源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | (predicted: Human, Mouse, Rat, Pig, ) |
產(chǎn)品應(yīng)用 | Flow-Cyt=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 48kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human Cyclin B1 around the phosphorylation site of Ser133 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq, Jul 2008]. Function: Essential for the control of the cell cycle at the G2/M (mitosis) transition. Subunit: Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10. Interacts with catalytically active RALBP1 and CDC2 during mitosis to form an endocytotic complex during interphase. Interacts with CCNF; interaction is required for nuclear localization. Subcellular Location: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, centrosome. Post-translational modifications: Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases. Phosphorylated by PLK1 at Ser-133 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-147 was also reported to be mediated by PLK1 but Ser-133 seems to be the primary phosphorylation site. Similarity: Belongs to the cyclin family. Cyclin AB subfamily. Database links: Entrez Gene: 891 Human Entrez Gene: 268697 Mouse Omim: 123836 Human SwissProt: P14635 Human SwissProt: P24860 Mouse Unigene: 23960 Human Unigene: 260114 Mouse Unigene: 380027 Mouse Unigene: 482545 Mouse Unigene: 9232 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 主要出現(xiàn)在G2期。Cyclin B是細(xì)胞周期調(diào)節(jié)必不可少的條件。 細(xì)胞周期素B1是細(xì)胞周期調(diào)節(jié)因子,它的異常表達(dá)將導(dǎo)致細(xì)胞周期發(fā)生紊亂,致使腫瘤形成. |
| 欧美喷潮喷水失禁合集 | www.亚洲555久久久 | 黄色视频网站免费观看 | 无码人妻AV免费一区 | 四川BBB搡BBB搡多人孕妇 | 四川老熟女偷人AA片 | 欧美精黑人一级A片蜜桃视频 | 黄大色黄大片女爽一次 | **夜色精品国产欧美乱 | 熟女俱乐部专干老妇女 | 无码秘 蜜桃一区二区三区 无码人妻一区二区三区在线 | 国产全肉乱妇杂乱视频 | 老熟女多毛一区二区三区四区五区 | 欧美 国产 亚洲视频 | 欧美一级特黄AA大片 | 寡妇高潮特黄毛片免费看 | 91丨国产丨精品丨丝袜 | 无码人妻精品一区二区蜜桃色欲 | 一级毛片在线看免费视频网站 | 国产精品久久久久无码AV | 中文字幕制服丝袜一区二区三区 | 中文字幕免费观看哔哔在线 | 国产精品18禁久久久久久白浆 | 欧美视频一区二区三区 | 欧美性猛交XXXX乱大交3 | 午夜福利手拍一区二区 | 人人躁人人爽人人爱夜夜躁游戏 | 97人妻精品一区二区三区 | 国产又黄又爽又色的免费蜜乳 | 日本熟妇六十路 五十路 | 国产69精品久久久久久久久久久久 | 东北女人毛多水多A片 | 欧美少妇大奶色交视频 | 特级西西西4444大胆无码 | 蜜桃无码人妻丰满熟妇区五十路i | 亚洲精品污一区二区三区 | 91人人网人人操人人爽 | 日韩精品一区二区三区在线 | 午夜理理伦电影A片无码新新娇妻 | 国产婬片lA片www777 |