產(chǎn)品編號 | bs-11690R-PE |
英文名稱 | Rabbit Anti-FIG4/PE Conjugated antibody |
中文名稱 | PE標(biāo)記的肌萎縮側(cè)索硬化癥相關(guān)蛋白FIG4抗體 |
別 名 | 5-bisphosphate 5-phosphatase; Fig4; FIG4_HUMAN; KIAA0274; ALS11; Phosphatidylinositol 3; hSac3; Phosphatidylinositol 3,5 bisphosphate 5 phosphatase; Polyphosphoinositide phosphatase; SAC domain containing protein 3; SAC domain-containing protein 3; SAC3. |
規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
說 明 書 | 100ul |
研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Sheep, Monkey, ) |
產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 104kDa |
細(xì)胞定位 | 細(xì)胞膜 |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human FIG4 (1-100aa) |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J. [provided by RefSeq, Jul 2008] Function: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. Subcellular Location: Endosome membrane. Localization requires VAC14 and PIKFYVE. DISEASE: Defects in FIG4 are the cause of Charcot-Marie-Tooth disease type 4J (CMT4J) [MIM:611228]. CMT4J is a recessive demyelinating, severe form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies characterized by severely reduced motor nerve conduction velocities (NCVs) (less than 38m/s) and segmental demyelination and remyelination, and primary peripheral axonal neuropathies characterized by normal or mildly reduced NCVs and chronic axonal degeneration and regeneration on nerve biopsy. Defects in FIG4 are the cause of amyotrophic lateral sclerosis type 11 (ALS11) [MIM:612577]. ALS is a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10%. Similarity: Contains 1 SAC domain. Database links: Entrez Gene: 9896 Human Entrez Gene: 103199 Mouse Omim: 609390 Human SwissProt: Q92562 Human SwissProt: Q91WF7 Mouse Unigene: 529959 Human Unigene: 277242 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 四川丰满少妇一级毛片 | 成人爱爱视频免费在线播放 | 黄网站在线看免费入口 | 特级毛片爽www免费版 | 蜜桃无码一区二高考教师 | 久久天天躁狠狠躁夜夜AV | 国产农村妇女精品一二区 | 景音先锋日韩欧美制服亚洲 | 十五分钟高清无码视频 | 久久人妻无码一区二区 | 亚洲欧美动漫偷拍 | www.老师自慰观看 | 久久亚洲精品无码Va白人极品 | 海角熟妇一区二区三区 | 噜啊噜在线成人A片观看 | 无码国产精品一区二区免费式直播 | 久久久亚洲熟妇熟女 | 中文字幕免费在线观看 | 欧美成人无码性狂猛XXX | 亚洲无 码A片在线观看麻豆 | 黄色网址网站老外中国女人 | 飘香影院午夜理论片A片 | 欧美熟妇BBB搡BBB | 国产精品a久久久久久久 | 91丝袜放荡丝袜脚交 | 无套内 少妇A片斗音 | 国产伦子伦对白视频免费 | 91精品人妻少妇无码影院 | 人妻精品一区二区在线 | 久久成人人人人精品欧 | 久久欧美性大无无码毛片 | 小向美奈子A片在线观看 | 在线免费观看黄色视频网站 | 国产农村一级特黄真人片 | 中文在线字幕观看电视剧 | 一级黄色视频在线观看 | 91在线无码精品秘 色 | 色婷婷五月一区二区三区 | 色欲a∨无码蜜臀av免费播 | 91精品久久久久久久久久浪潮 |