| 產(chǎn)品編號 | bs-11430R-APC |
| 英文名稱 | Rabbit Anti-NPSR1/APC Conjugated antibody |
| 中文名稱 | APC標(biāo)記的神經(jīng)肽S受體1/G蛋白偶聯(lián)受體154抗體 |
| 別 名 | GPR154; ASRT2; G protein coupled receptor 154; G protein coupled receptor for asthma susceptibility; G protein coupled receptor PGR14; GPR 154; gpr154; GPRA; MVTR; Neuropeptide S receptor 1; Neuropeptide S receptor; nps receptor; NPSR 1; NPSR; NPSR1; PGR 14; PGR14; PGR-14; Vasopressin receptor related receptor 1; VRR 1; VRR1; NPSR1_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞膜受體 G蛋白偶聯(lián)受體 G蛋白信號 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 43kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NPSR1 (201-300aa) |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR154 (G-protein coupled receptor 154), also known as NPSR1 (neuropeptide S receptor), GPRA (G-protein coupled receptor for asthma susceptibility) or PGR14, is a 371 amino acid protein that is thought to play a role in autocrine or paracrine signaling pathways. Ubiquitously expressed, GPR154 exists as nine alternatively spliced isoforms. Defects in the gene encoding GPR154 is the cause of asthma-related traits type 2 (ASRT2). Function: Neuropeptide S receptor 1 (GPR154) is a receptor for Neuropeptide S. It is expressed on the epithelia of several organs including the intestine, and appears to be upregulated in inflammation. It is upregulated in macrophages after antigen challenge and is involved in the pathogenesis of asthma and other IgE-mediated diseases. Subcellular Location: Cell Membrane and Cytoplasmic Tissue Specificity: Ubiquitous. Isoform 1 is predominantly expressed in smooth muscle. Isoform 4 is predominantly expressed in epithelial cells. In bronchial biopsies, it is expressed in smooth muscle cells of asthma patients, but not in control patients; whereas in epithelial cells, its expression is consistently stronger in asthma patients. DISEASE: Defects in NPSR1 are a cause of asthma-related traits type 2 (ASRT2) [MIM:608584]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. Similarity: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. Database links: Entrez Gene: 387129 Human Entrez Gene: 319239 Mouse Omim: 608595 Human SwissProt: Q6W5P4 Human SwissProt: Q8BZP8 Mouse Unigene: 652373 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 神經(jīng)肽S(neuropeptide S,NPS)是2002年發(fā)現(xiàn)的一種神經(jīng)肽,由20個(gè)氨基酸組成,通過激活其受體NPSR而發(fā)揮作用。NPS/NPSR系統(tǒng)參與調(diào)節(jié)覺醒和睡眠、焦慮、攝食、免疫等功能。神經(jīng)肽S（neuropeptide S，NPS），通過激活其同源受體（NPSR），并引發(fā)細(xì)胞內(nèi) Ca2+動(dòng)員，進(jìn)而調(diào)控失眠和憂慮，具有提高實(shí)驗(yàn)動(dòng)物的清醒程度以及有減少焦慮的作用。 |
