强伦轩一级A片在线观看,中文字幕乱码人妻二区三区,鲁鲁狠狠狠7777一区二区,西西4444www无码精品
掃碼關(guān)注公眾號(hào)           掃碼咨詢(xún)技術(shù)支持           掃碼咨詢(xún)技術(shù)服務(wù)
  
客服熱線(xiàn):400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
陕西少妇性生交BBBBBB,911亚洲精品无码成人A片在线
Rabbit Anti-SCN1B/Cy7 Conjugated antibody (bs-6687R-Cy7)
訂購(gòu)熱線(xiàn):400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-6687R-Cy7
英文名稱(chēng) Rabbit Anti-SCN1B/Cy7 Conjugated antibody
中文名稱(chēng) Cy7標(biāo)記的鈉離子通道β1抗體
別    名 GEFSP1; SCN1B_HUMAN; sodium channel beta 1 subunit; Sodium channel subunit beta 1; Sodium channel subunit beta-1; Sodium channel voltage gated type I beta.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢(xún)價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  通道蛋白  細(xì)胞膜受體  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, )
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 22kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SCN1B
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.
Tissue specificity; Abundantly expressed in skeletal muscle, heart and brain.

Function:
Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

Subunit:
The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2 and beta-3. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 is covalently linked by disulfide bonds. Beta-1 or beta-3 subunits associate with neurofascin. Associates with SCN10A (By similarity).

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
The overall expression of isoforms 1 and 2 is very similar. Isoform 1 is abundantly expressed in skeletal muscle, heart and brain. Isoform 2 is highly expressed in brain and skeletal muscle and present at a very low level in heart, placenta, lung, liver, kidney and pancreas. In brain, isoform 2 is most abundant in the cerebellum, followed by the cerebral cortex and occipital lobe, while isoform 1 levels are higher in the cortex compared to the cerebellum. Isoform 2 is expressed in many regions of the brain, including cerebellar Purkinje cells, cortex pyramidal neurons and many of the neuronal fibers throughout the brain (at protein level). Also detected in dorsal root ganglion, in fibers of the spinal nerve and in cortical neurons and their processes (at protein level).

DISEASE:
Defects in SCN1B are the cause of generalized epilepsy with febrile seizures plus type 1 (GEFS+1) [MIM:604233]. Generalized epilepsy with febrile seizures-plus refers to a rare autosomal dominant, familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. GEFS+ is a disease combining febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity.
Defects in SCN1B are the cause of Brugada syndrome type 5 (BRGDA5) [MIM:612838]. A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.

Similarity:
Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Database links:

Entrez Gene: 6324 Human

Entrez Gene: 20266 Mouse

Entrez Gene: 29686 Rat

Omim: 600235 Human

SwissProt: Q07699 Human

SwissProt: P97952 Mouse

SwissProt: Q00954 Rat

Unigene: 436646 Human

Unigene: 1418 Mouse

Unigene: 4958 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 m.nmgps.com 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
色欲淫香综合插插插影视 | 欧美黄色成人视频 | 一级毛片久久久久久久女人18 | 久久夜色精品国产欧美乱极品 | 国产美女裸体无遮挡免费视频 | 亚洲AV无码蜜桃希岛爱理 | 无码经典中文国产凹凸 | 99久久人妻无码精品系列江西 | 妇女敕BBB搡BBBBBB搡 | 最好看的2019中文大全在线观看 | 精品无码视频在线免费观看 | 人妻少妇91精品一区黑人 | 欧美精品人妻无码一区久爱 | 一级a性色生活片久久 | 国产农村熟妇出轨videos | 欧美日韩中文字幕无码 | 国内自拍真实伦在线观看 | 亚洲精品久久激情国产片 | 黄色国产视频在线免费观看 | 国产精品在线观看视频 | 人与物videos另类与蛇交 | 高跟肉丝少妇A片在线 | 又粗又深又猛又爽无遮挡 | 一级黄色片在线免费看 | 蜜桃秘 无码一区二区三区 91久久人澡人人添人人爽 | 免费无码AV片在线观看 | 国产人妻人伦AV又粗又大百度云 | 人妻夜夜女同中文字幕 | 水多多无码爆乳人妻 | 国产又粗又黄又爽视频 | 无码人妻AV一区二区三区中文 | 黑丝美女免费国产黄片 | 亚洲日日做日日谢日日鲁 | 小14萝裸体毛片免费看 | 亚洲天堂毛片在线观看 | A片久久国产首拍精品AV | 17c人妻无码一区二区三区 | 国产一级婬乱A片牛牛视频小说 | 強行糟蹋人妻HD中文 | 荡妇肉欲乱色欲av浪潮 | 免费A片呻吟高清视频播放 性一交一乱一色一视频麻豆 |