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Rabbit Anti-Bassoon/Biotin Conjugated antibody (bs-0275R-Bio)
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-0275R-Bio
英文名稱 Rabbit Anti-Bassoon/Biotin Conjugated antibody
中文名稱 生物素標(biāo)記的鋅指蛋白231抗體
別    名 Bassoon; BSN; KIAA0434; Neuronal double zinc finger protein; Presynaptic cytomatrix protein; Protein bassoon; Zinc finger protein 231; ZNF 231; ZNF231; Neuronal double zinc finger protein; Zinc-finger protein 231; BSN_HUMAN; ZNF 231.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  鋅指蛋白  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, )
產(chǎn)品應(yīng)用 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 432kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human BSN (2901-3000aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Neurotransmitters are released from a specific site in the axon terminal called the active zone, which is composed of synaptic vesicles and a meshwork of cytoskeleton underlying the plasma membrane. The protein encoded by this gene is thought to be a scaffolding protein involved in organizing the presynaptic cytoskeleton. The gene is expressed primarily in neurons in the brain. A similar gene product in rodents is concentrated in the active zone of axon terminals and tightly associated with cytoskeletal structures, and is essential for regulating neurotransmitter release from a subset of synapses. [provided by RefSeq, Jul 2008].

Function:
Is thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act through binding to ERC2/CAST1. Essential in regulated neurotransmitter release from a subset of brain glutamatergic synapses. Involved in the formation of the retinal photoreceptor ribbon synapses.

Subunit:
Interacts with ERC2/CAST1, RIMS1 and UNC13A. Part of a complex consisting of ERC2, RIMS1 and BSN.

Subcellular Location:
Cytoplasm. Cell junction, synapse, synaptosome. Cytoplasm, cytoskeleton. Note=Localized to the active zone of presynaptic density.

Tissue Specificity:
Exclusively expressed in brain.

Post-translational modifications:
Myristoylated. The N-terminal myristoylation is not sufficient for presynaptic localization.

Database links:

Entrez Gene: 8927 Human

Entrez Gene: 12217 Mouse

Entrez Gene: 29138 Rat

Omim: 604020 Human

SwissProt: O43161 Human

SwissProt: Q9UPA5 Human

SwissProt: O88737 Mouse

SwissProt: O88778 Rat

Unigene: 194684 Human

Unigene: 20425 Mouse

Unigene: 29999 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

鋅指蛋白是80年代中期發(fā)現(xiàn)的一類(lèi)DNA結(jié)合蛋白,在真核生物中,鋅指蛋白可能是最大的一類(lèi)DNA結(jié)合蛋白,并且由鋅指蛋白調(diào)控基因表達(dá)是發(fā)育和其他過(guò)程的一個(gè)非常普遍的現(xiàn)象。在最近的幾年中,發(fā)現(xiàn)某些鋅指蛋白對(duì)肌肉的發(fā)育具有重要的調(diào)節(jié)作用。
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