產(chǎn)品編號 | bs-0114M-PE-Cy5.5 |
英文名稱 | Mouse Anti-Aromatase/PE-Cy5.5 Conjugated antibody |
中文名稱 | PE-Cy5.5標(biāo)記的芳香化酶抗體 |
別 名 | Cytochrome p450 19A1; Estrogen synthetase; ARO 1; ARO; ARO1; CPV; CYPXIX; Cytochrome P450 19A1; Cytochrome P450 family 19 subfamily A polypeptide 1; MGC104309; P 450AROM; P450AROM; CP19A_HUMAN; Cytochrome P-450AROM. |
規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
說 明 書 | 100ul |
研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 激酶和磷酸酶 合成與降解 |
抗體來源 | Mouse |
克隆類型 | Polyclonal |
交叉反應(yīng) | Human, (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) |
產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 55kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human Aromatase N-terminus |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: Aromatase is a key enzyme in steroidogenesis and plays an important role in sexual differentiation, oestrogen biosynthesis, fertility and carcinogenesis. It is highly conserved amongst mammals, and is highly expressed in placental tissue. Many environmental chemicals may influence aromatase activity and thereby disrupt endocrine function. Function: Catalyzes the formation of aromatic C18 estrogens from C19 androgens. Subcellular Location: Membrane; Peripheral membrane protein. Tissue Specificity: Brain, placenta and gonads. DISEASE: Aromatase excess syndrome (AEXS) [MIM:139300]: An autosomal dominant disorder characterized by increased extraglandular aromatization of steroids that presents with heterosexual precocity in males and isosexual precocity in females. Note=The disease is caused by mutations affecting the gene represented in this entry. Aromatase deficiency (AROD) [MIM:613546]: A rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In adult females, manifestations include delay of puberty, breast hypoplasia and primary amenorrhoea with multicystic ovaries. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the cytochrome P450 family. Database links: Entrez Gene: 1588 Human Entrez Gene: 13075 Mouse Omim: 107910 Human SwissProt: P19098 Chicken SwissProt: P11511 Human SwissProt: P28649 Mouse Unigene: 260074 Human Unigene: 478781 Mouse Unigene: 5199 Mouse Unigene: 21402 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 細(xì)胞色素氧化酶p450; 是一種微粒體酶系統(tǒng),催化睪酮經(jīng)三步連續(xù)強(qiáng)化轉(zhuǎn)變成17-β-雌二醇,在反應(yīng)中睪酮作為激素原。 細(xì)胞色素P450主要分布在內(nèi)質(zhì)網(wǎng)和線粒體內(nèi)膜上,作為一種末端加氧酶,參與了生物體內(nèi)的甾醇類激素合成等過程。 近年來,對細(xì)胞色素P450的結(jié)構(gòu)、功能特別是對其在藥物代謝中的作用的研究有了較大的進(jìn)展。 最新研究表明細(xì)胞色素P450還是藥物代謝過程中的關(guān)鍵酶,而且對細(xì)胞因子和體溫調(diào)節(jié)都有重要影響。 芳香化酶-細(xì)胞色素P450作為和藥物代謝及細(xì)胞因子相關(guān)的重要酶類,在藥物代謝和免疫中起著相當(dāng)重要的作用,對于它的研究將有助于新藥的開發(fā),并能幫助人們更加清楚的認(rèn)識藥物的代謝途徑,在未來的新藥中減少副作用,增加藥物療效。隨著對細(xì)胞色素P450研究的深入,將有更多相關(guān)的藥物代謝途徑被發(fā)現(xiàn),人們開發(fā)新藥的視野將更加開闊,新藥開發(fā)的速度也將加快,質(zhì)量進(jìn)一步提高。 鑒于P450的研究無論在理論上探索生物的生理代謝、選擇進(jìn)化和生物與環(huán)境的關(guān)系方面,或在環(huán)境保護(hù)、農(nóng)業(yè)生態(tài)、生物防治、作物基因工程和醫(yī)藥衛(wèi)生等應(yīng)用方面,都有廣泛的實踐意義,因此,應(yīng)該受到更大的關(guān)注和重視。 |
| 国产女性无套免费网站 | 影音先锋在线观看资源 | 真实的国产乱ⅩXXX88 | 欧一美—美–交–黄–片 | 黄色视频免费看亚洲 | 内射囯产旡码丰满少妇 | 空姐一级毛片免费看 | 无码人妻精品中文字幕免费时间 | 欧美午夜免费三级片 | www.中文字幕在线 | 色欲av永久无码精品无码蜜桃 | 蜜桃av秘 无码一区三区 | 成人污网站在线看 | 国产日本欧洲亚洲 | 午夜视频免费观看 | 国产一二三区在线观看 | 国产高清在线视频 | 久久精品人妻一区二区三区 | 国产麻豆剧传媒免费观看 | 人妻体体内射精一区二区 | 亚洲精品污一区二区三区 | 91在线无码精品秘 软件网站 | 国产无码中文字幕亚洲 | 91久久精品人妻一区二区三区蜜桃 | 西西美女裸体视频久久 | 精品一区二区三区不卡 | 手机在线观看AV | 免费在线观看AV | 蜜臀久久99精品久久久久久基情 | 国产又色又猛又粗 | 无码视频一区二区三区 | 91人妻无码一区二区三区 | 久久嫩草av一级无码专区 | 国产寡妇亲子伦一区二区三区 | 91久久久无码精品不卡A片直播 | 国产成人三级一区二区在线观看一 | 专门看黄色视频的网站 | 国产成人无码免费视频 | 亚洲AV无码成人精品区国产 | 黄色网址视频观看大全 |