| 產(chǎn)品編號(hào) | bs-0922R-AP |
| 英文名稱 | Rabbit Anti-Neurogenin 3/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的神經(jīng)元素3抗體 |
| 別 名 | NGN3; neurogenin 3; Neurog3; Neurogenin3; Neurogenin-3; ATH4B; Atoh5; Math4B; NEUROG3; ngn3; OTTHUMP00000019730; Protein atonal homolog 5. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, (predicted: Rat, Dog, Cow, Sheep, ) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 23kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NGN3 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Neurogenin-3 (NEUROG3) is expressed in endocrine progenitor cells and is required for endocrine cell development in the pancreas and intestine (Wang et al., 2006 [PubMed 16855267]). It belongs to a family of basic helix-loop-helix transcription factors involved in the determination of neural precursor cells in the neuroectoderm. Function: Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types. Subcellular Location: Nucleus. DISEASE: Defects in NEUROG3 are the cause of diarrhea type 4 (DIAR4) [MIM:610370]. DIAR4 is a characterized by severe, life-threatening watery diarrhea associated with generalized malabsorption and a paucity of enteroendocrine cells. Similarity: Contains 1 basic helix-loop-helix (bHLH) domain. Database links: Entrez Gene: 50674 Human Entrez Gene: 11925 Mouse Omim: 604882 Human SwissProt: Q9Y4Z2 Human SwissProt: P70661 Mouse Unigene: 532682 Human Unigene: 57236 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 神經(jīng)生物學(xué)相關(guān)蛋白（Neurobiology） Ngn3屬于bHLH家族蛋白，是胰腺發(fā)育過程中短暫表達(dá)的蛋白，可能是胰腺內(nèi)分泌細(xì)胞系的定向因子，一般在成熟胰島中不存在。 Ngn3的表達(dá)會(huì)導(dǎo)致胰腺內(nèi)分泌細(xì)胞數(shù)的增加外分泌細(xì)胞數(shù)的減少。因而胰島β細(xì)胞并不是完全靠干細(xì)胞分化產(chǎn)生，主要是通過已分化胰島β細(xì)胞的分裂增殖。 但近年來，有學(xué)者認(rèn)為：Ngn3雖在胰腺發(fā)育中短暫表達(dá)，但是否存在使胰島干細(xì)胞或前體細(xì)胞自我更新的能力尚未明確定論。 |
