| 產(chǎn)品編號(hào) | bs-23857R |
| 英文名稱 | TFF2 Rabbit pAb |
| 中文名稱 | 三葉肽因子2抗體 |
| 別 名 | TFF2_HUMAN; Trefoil factor 2; SML1; SP; Spasmolysin; Spasmolytic polypeptide(SP); |
| 研究領(lǐng)域 | 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 生長因子和激素 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse (predicted: Rat,Pig) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 12/14 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TFF2: 31-100/129 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008] Function: Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity). Subcellular Location: Secreted. Tissue Specificity: Stomach. Similarity: Contains 2 P-type (trefoil) domains. SWISS: Q03403 Gene ID: 7032 Database links: Entrez Gene: 7032 Human Entrez Gene: 21785 Mouse SwissProt: Q03403 Human SwissProt: Q03404 Mouse 三葉肽可能使黏膜凝膠產(chǎn)生更大的穩(wěn)定性,使胃黏膜對(duì)各種損傷因子的防御能力增強(qiáng)。三葉肽在誘導(dǎo)上皮修復(fù)上的直接作用,可用于許多胃腸道疾病。它作為輔助劑或取代皮質(zhì)類固醇或其他免疫抑制劑，在潰瘍病及炎癥性腸病的治療上可能是一個(gè)突破。 |
| 產(chǎn)品圖片 |
Paraformaldehyde-fixed, paraffin embedded (human gastric carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TFF2) Polyclonal Antibody, Unconjugated (bs-23857R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (mouse stomach tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TFF2) Polyclonal Antibody, Unconjugated (bs-23857R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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