| 產(chǎn)品編號 | bs-17348R |
| 英文名稱 | HOGA1 Rabbit pAb |
| 中文名稱 | HOGA1蛋白抗體 |
| 別 名 | 4 hydroxy 2 oxoglutarate aldolase 1; C10orf65; DHDPS like protein; DHDPS2; DHDPSL; Dihydrodipicolinate synthase like; Dihydrodipicolinate synthase like, mitochondrial; Dihydrodipicolinate synthetase homolog 2; FLJ37472; HOGA1; HOGA1_HUMAN; HP3; mitochondr |
| 研究領(lǐng)域 | 細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 新陳代謝 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse (predicted: Human) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 32 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HOGA1: 26-130/327 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
DHDPSL is a 327 amino acid mitochondrial protein that catalyzes the last step in the hydroxyproline metabolic pathway. Existing as two alternatively spliced isoforms, DHDPSL is expressed in kidney and liver and is inhibited by divalent cations. Defects in the gene that encode DHDPSL are the cause of primary hyperoxalurea type III (HP3), a disorder of calcium oxalate nephrolithiasis. Patients with HP3 excrete urine with elevated levels of oxalate and L-glycerate. The DHDPSL gene maps to human chromosome 10, which contains over 800 genes and 135 million nucleotides. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria SWISS: Q86XE5 Gene ID: 112817 Database links: Entrez Gene: 112817 Human Entrez Gene: 67432 Mouse Omim: 613597 Human SwissProt: Q86XE5 Human SwissProt: Q9DCU9 Mouse Unigene: 180346 Human Unigene: 24196 Mouse Unigene: 13905 Rat |
| 產(chǎn)品圖片 |
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (HOGA1) Polyclonal Antibody, Unconjugated (bs-17348R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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