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Myotrophin Rabbit pAb (bs-11891R)  
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50ul/1180.00元
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200ul/2800.00元
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產(chǎn)品編號 bs-11891R
英文名稱 Myotrophin Rabbit pAb
中文名稱 顆粒細胞分化蛋白抗體
別    名 FLJ31098; FLJ99857; GCDP; Granule cell differentiation protein; MTPN; MTPN_HUMAN; Myotrophin; Protein V 1; Protein V-1; V 1; MTPN_HUMAN.  
Specific References  (1)     |     bs-11891R has been referenced in 1 publications.
[IF=2.379] Jieting Liu. et al. Identification of robust diagnostic and prognostic gene signatures in different grades of gliomas: a retrospective study. Peerj. 2021 May;9:e11350  WB ;  Human.  
研究領(lǐng)域 心血管  細胞生物  神經(jīng)生物學  細胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Chicken,Dog)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 13 kDa
檢測分子量
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from humam Myotrophin/GCDP: 41-118/118 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. [provided by RefSeq, Jul 2008]

Function:
Potential role in cerebellar morphogenesis. May function in differentiation of cerebellar neurons, particularly of granule cells. Seems to be associated with cardiac hypertrophy.

Subunit:
Interacts with RELA (By similarity). Interacts with the heterodimer formed by CAPZA1 and CAPZB.

Subcellular Location:
Cytoplasm (Probable). Nucleus (By similarity). Cytoplasm, perinuclear region (By similarity).

Tissue Specificity:
Ubiquitous.

Similarity:
Belongs to the myotrophin family.
Contains 3 ANK repeats.

Database links:

Entrez Gene: 136319 Human

Entrez Gene: 14489 Mouse

Entrez Gene: 79215 Rat

Entrez Gene: 403487 Dog

Omim: 606484 Human

SwissProt: Q863Z4 Dog

SwissProt: P58546 Human

SwissProt: P62774 Mouse

SwissProt: P62775 Rat

SwissProt: Q7T2B9 Zebrafish

Unigene: 602015 Human

Unigene: 182746 Mouse

Unigene: 3239 Rat

Unigene: 75187 Zebrafish



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