| 產(chǎn)品編號(hào) | bs-11168R |
| 英文名稱 | RASSF5 Rabbit pAb |
| 中文名稱 | RASSF5抗體 |
| 別 名 | ras association domain-containing family protein 5; RASF5_HUMAN; New ras effector 1; Regulator for cell adhesion and polarization enriched in lymphoid tissues; RAPL; Nore1; Rapl. |
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Specific References (2) | bs-11168R has been referenced in 2 publications.
[IF=5.9] Yang, Rui, et al. "Rassf5 and Ndr kinases act in a novel pathway regulating neuronal polarity through Par3 phosphorylation." Journal of Cell Science (2014): jcs-146696. Mouse.
[IF=3.383] Guangduo Zhu et al. Exosomal miR-532–5p from bone marrow mesenchymal stem cells reduce intervertebral disc degeneration by targeting RASSF5. Exp Cell Res. 2020 Aug 15;393(2):112109. WB ; Rat.
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| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 G蛋白信號(hào) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 46 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RASSF5: 321-418/418 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Function: Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS1 and KRAS induced apoptosis. Subunit: Interacts directly with activated HRAS1; a RASSF5-STK4/MST1 complex probably associates with activated HRAS1. Interacts with KRAS. Probably interacts with Ras-like GTPases RRAS, RRAS2, MRAS, RAP1B, RAP2A and RALA. Can self-associate. Interacts with RSSF1 isoform A. The RSSF1 isoform A-RSSF5 heterodimer probably mediates the association of RSSF1 with HRAS1. Isoform 2 interacts with activated RAP1A andITGAL/LFA-1. Binds STK4/MST1, inhibiting STK4/MST1 autoactivation. Subcellular Location: Cytoplasm. Cytoplasm, cytoskeleton. unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A. Tissue Specificity: Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors. Similarity: Contains 1 phorbol-ester/DAG-type zinc finger. Contains 1 Ras-associating domain. Contains 1 SARAH domain. SWISS: Q8WWW0 Gene ID: 83593 Database links: Entrez Gene: 83593 Human Entrez Gene: 54354 Mouse Omim: 607020 Human SwissProt: Q8WWW0 Human SwissProt: Q5EBH1 Mouse Unigene: 497579 Human Unigene: 248291 Mouse Unigene: 36106 Rat |
