| 產(chǎn)品編號 | bs-4568R |
| 英文名稱 | EGF Rabbit pAb |
| 中文名稱 | 抗表皮生長因子抗體 |
| 別 名 | beta urogastrone; EGF; Egf; EGF_HUMAN; Epidermal Growth Factor; Epidermal Growth Factor; HOMG4; OTTHUMP00000219721; OTTHUMP00000219722; Pro epidermal growth factor; URG; Urogastrone. |
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Specific References (3) | bs-4568R has been referenced in 3 publications.
[IF=8.025] Xinxin Lan. et al. Xanthan gum/oil body-microgel emulsions with enhanced transdermal absorption for accelerating wound healing. INT J BIOL MACROMOL. 2022 Sep;: WB ; Mouse.
[IF=4.57] Niwa, Atsuko, et al. "Voluntary exercise induces neurogenesis in the hypothalamus and ependymal lining of the third ventricle." Brain Structure and Function: 1-14. IHC-P ; Rat.
[IF=2.74] Rui Feng. et al. Progesterone regulates inflammation and receptivity of cells via the NF-κB and LIF/STAT3 pathways. THERIOGENOLOGY. Theriogenology. 2022 Jul;186:50 WB ; Bovine.
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| 研究領(lǐng)域 | 腫瘤 信號轉(zhuǎn)導(dǎo) 生長因子和激素 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse (predicted: Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:50-200,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 5.8/133 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse EGF: 1-53/53 (977-1029/1217) |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Epidermal growth factor (EGF) is an acid- and heat-stable 53 amino acid protein originally found in rodents and humans. It has been shown to be a potent mitogen for a variety of cell types both in vivo and in vitro. EGF binds to the EGF receptor on the surface of cells and mediates intrinsic phosphorylation of the receptor on tyrosine residues. It has been detected in nearly all body fluids, such as urine (urogastrone), saliva, milk and platelet-rich plasma. EGF, TGF?and vaccinia virus growth factor exhibit 30-40% amino acid homology. Several additional members of the EGF/TGF family have been described; these include Cripto, Amphiregulin and the heparin-binding EGF-like growth factor. Amphiregulin and the heparin-binding EGF-like growth factor both bind to the EGF receptor.
Subcellular Location: Membrane. Tissue Specificity: Expressed in kidney, salivary gland, cerebrum and prostate. SWISS: P01132 Gene ID: 13645 Database links: Entrez Gene: 13645 Mouse Entrez Gene: 1950 Human Omim: 131530 Human SwissProt: P01133 Human SwissProt: P01132 Mouse Unigene: 419815 Human Tissue Specificity : Expressed in kidney, salivary gland, cerebrum and prostate. Involvement in disease:Defects in EGF are the cause of hypomagnesemia type 4 (HOMG4); also known as renal hypomagnesemia normocalciuric. HOMG4 is a disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to mederate psychomotor retardation, and brisk tendon reflexes. |
