| 產(chǎn)品編號 | bs-2654R |
| 英文名稱 | LTB4-R1 Rabbit pAb |
| 中文名稱 | 白三烯B4受體1抗體 |
| 別 名 | Leukotriene B4 receptor 1; Leukotriene B4 receptor; BLT; BLT1; BLTR; Chemokine receptor like 1; CMKRL1; G protein coupled receptor 16; GPR16; Leukotriene B4 G Protein coupled receptor; LTB4 R 1; LTB4R 1; LTB4R; LTBR1; P2RY7; P2Y purinoceptor 7; P2Y7; Puri |
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Specific References (4) | bs-2654R has been referenced in 4 publications.
[IF=5.093] Zhao, Xiu-Juan. et al. Therapeutic effect of the sulforaphane derivative JY4 on ulcerative colitis through the NF-κB-p65 pathway. INFLAMMOPHARMACOLOGY. 2022 Aug;:1-12 IHC ; Mouse.
[IF=4.57] Zinn, Sebastian, et al. "The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons." Journal of Biological Chemistry (2017): jbc-M116. IHC-F ; Mouse.
[IF=3.491] Malihe Eskandarpour. et al. Leukotriene B4 and Its Receptor in Experimental Autoimmune Uveitis and in Human Retinal Tissues: Clinical Severity and LTB4 Dependence of Retinal Th17 Cells. Am J Pathol. 2021 Feb;191:320 IF ; Human.
[IF=0] Wculek, S. Pre-metastatic neutrophils directly support highly tumourigenic breast cancer cells during lung metastasis via a leukotriene-ERK1/2 axis. Diss. UCL (University College London), 2016. FCM ; Mouse.
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| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) G蛋白偶聯(lián)受體 G蛋白信號 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Rabbit,Pig,Cow,Dog,GuineaPig,Horse) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 39 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LTB4-R1: 101-200/352 <Cytoplasmic> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Leukotriene B4 Receptor is a member of the GPCR family (subfamily:chemoattractant). It is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response. It has been reported in blood, bone marrow, brain, heart, liver, and skeletal muscle. In addition, it has been shown to be highly expressed in leukocytes and lymphoid tissues such as spleen, thymus, and lymph node. ESTs have been isolated from B cell/lung/testis, breast, colon, eye, kidney, skin, spleen, testis, and tonsil libraries. Function: Receptor for extracellular ATP, UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver. High level of expression in lymphoid tissues. Post-translational modifications: Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: Q15722 Gene ID: 1241 Database links: Entrez Gene: 1241 Human Omim: 601531 Human SwissProt: Q15722 Human Unigene: 567248 Human Unigene: 727320 Human |
