產(chǎn)品編號(hào) | bs-0279R |
英文名稱(chēng) | VEGFA Rabbit pAb |
中文名稱(chēng) | 血管內(nèi)皮生長(zhǎng)因子抗體 |
別 名 | Vascuoar endothelial growth factor A; VEGF A; vascular endothelial growth factor A isoform 2 precursor; MGC70609; MVCD1; VEGF; VPF; VEGFA_HUMAN; VEGF-A; Vascular permeability factor(VPF); |
![]() |
Specific References (40) | bs-0279R has been referenced in 40 publications.
|
研究領(lǐng)域 | 腫瘤 心血管 生長(zhǎng)因子和激素 糖尿病 |
抗體來(lái)源 | Rabbit |
克隆類(lèi)型 | Polyclonal |
交叉反應(yīng) | Mouse,Rat |
產(chǎn)品應(yīng)用 | WB=1:500-1000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
理論分子量 | 24 kDa |
檢測(cè)分子量 | |
細(xì)胞定位 | 分泌型蛋白 |
性 狀 | Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human VEGF: 27-120/232 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
PubMed | PubMed |
產(chǎn)品介紹 |
This gene product is a member of the PDGF/VEGF growth factor family. It is a mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Also, alternative translation initiation from non-AUG (CUG) and AUG start sites in some transcript variants, give rise to additional isoforms. [provided by RefSeq]. Function: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Subunit: Homodimer; disulfide-linked. Also found as heterodimer with PGF. Subcellular Location: Secreted. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin. Tissue Specificity: Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. DISEASE: Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1 (MVCD1) [MIM:603933]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Similarity: Belongs to the PDGF/VEGF growth factor family. SWISS: P15692 Gene ID: 7422 Database links: Entrez Gene: 7422 Human Entrez Gene: 22339 Mouse Omim: 192240 Human SwissProt: P15692 Human SwissProt: Q00731 Mouse Unigene: 73793 Human Unigene: 282184 Mouse Unigene: 1923 Rat
生長(zhǎng)因子和激素(Growth Factor and Hormones) 血管內(nèi)皮細(xì)胞生長(zhǎng)因子(VEGF)是一種特異作用于血管內(nèi)皮細(xì)胞的多功能細(xì)胞因子,它能引起血管通透性增加,引起細(xì)胞外基質(zhì)成分改變,誘導(dǎo)血管形成.在炎癥、創(chuàng)傷愈合、心臟缺血、動(dòng)脈粥樣硬化、糖尿病性視網(wǎng)膜病變及腫瘤形成等與血管生成和病變有關(guān)的諸多病理過(guò)程中起重要作用. VEGF與血管生成有關(guān),從而也與腫瘤生長(zhǎng)也有很大關(guān)系,近年來(lái)受到很多關(guān)注. |
產(chǎn)品圖片 |
Sample: Kidney(Mouse) Lysate at 30 ug
Primary: Anti-VEGF (bs-0279R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
Predicted band size: 24 kD
Observed band size: 25 kD
|
| 国产又爽 又黄 微信号 | 免费黃色三級片国产片 | 香蕉一级婬片A片久久精 | 性爱一级毛片丰满少妇 | 中文字幕高清无码视频 | 青草综合一区二区三区 | 黄色免费网站在线观看 | 欧美性猛交XXXX乱大交3未删减版 | 色狠狠色综合久久久绯色AⅤ影视 | 无码人妻aV一区二区三区色欲 | 国产裸体免费无遮挡香港特辑 | EEUSS鲁片一区二区三区四虎 | 一级香蕉视频在线观看 | 少女哔哩哔哩视频在线看中文版 | 波多野结衣乳视频在线观看 | www久久久红桃视频国产 | 亚洲国产精品国自产拍AⅤ 国产成人无码一区二区三区 | 破坏版无码A在线播放 | 午夜理理伦电影A片无码新新娇妻 | 欧美一区二区三区在线视频 | 91精品国产综合久久久蜜股 | 久久久国产精品免费A片分天美 | 亚洲精品成a人在线观看 | 欧美人与性囗牲恔配 | 国产69精品久久久久久久久久久久 | 海角社区偷拍视频在线观看 | 精品无码A片一区二区蜜桃 6699人人人人人人人人 | 亚洲裸体漫画在线观看 | 无码人妻精品一区二区三区老鸭窝 | 特级欧美婬片免费高直播播放 | 国产人妻A片三毛片 | 黄片儿高清无码免费观看 | 国内蜜桃臀在线观看免费视频一区二区h | 性一交一乱一交A片久 | av黄色一区二区三区入口 | 欧美黑人又大又粗XXXXX吞精 | 日本不卡视频在线播放 | 成人无码情人色情A片 | 国产日韩成人精品一区二区 | 国产精品自拍视频 |