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CTGF Rabbit pAb (bs-0743R)  
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產(chǎn)品編號(hào) bs-0743R
英文名稱 CTGF Rabbit pAb
中文名稱 結(jié)締組織生長(zhǎng)因子抗體
別    名 CCN 2; CCN-2; CCN2; Connective Tissue Growth Factor; Hcs 24; Hcs24; Hypertrophic chondrocyte specific protein 24; Hypertrophic chondrocyte-specific gene product 24; Insulin-like Growth Factor-Binding Protein 8; MGC102839; NOV 2; NOV2; Connective tissue growth factor; CCN family member 2; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth-binding protein 8; IBP-8; IGF-binding protein 8; IGFBP8; IGFBP-8; connective tissue growth factor precursor; CTGF_HUMAN.  
Specific References  (13)     |     bs-0743R has been referenced in 13 publications.
[IF=8.46] Ciamporcero, E., et al. "YAP activation protects urothelial cell carcinoma from treatment-induced DNA damage." Oncogene (2015).  WB ;  Human.  
[IF=6.854] Ciamporcero et al. YAP activation protects urothelial cell carcinoma from treatment-induced DNA damage. (2016) Oncogene. 35:1541-53  WB ;  Human.  
[IF=4.486] Deng Z et al. Dabigatran ameliorates airway smooth muscle remodeling in asthma by modulating Yes‐associated protein. J Cell Mol Med. 2020 Jul;24(14):8179-8193.  WB&ICF ;  Mouse&Human.  
[IF=4.486] Deng Z et al. Dabigatran Ameliorates Airway Smooth Muscle Remodeling in Asthma by Modulating Yes-associated Protein. J Cell Mol Med. 2020 Jun 15.  WB ;  mouse.  
[IF=4.174] Zhao, Boyuan. et al. Shear stress regulates the migration of suspended breast cancer cells by nuclear lamina protein A/C and large tumor suppressor through yes-associated protein. Hum Cell. 2022 Jan;:1-16  WB ;  Human.  
[IF=4.101] Yu Guo. et al. RepSox effectively promotes the induced differentiation of sheep fibroblasts into adipocytes via the inhibition of the TGF?β1/Smad pathway. Int J Mol Med. 2021 Aug;48(2):1-13  WB ;  Sheep.  
[IF=3.423] Zhe Sui. et al. Ginsenoside Rg3 has effects comparable to those of ginsenoside re on diabetic kidney disease prevention in db/db mice by regulating inflammation, fibrosis and PPARγ. MOL MED REP. 2023 Apr;27(4):1-10  IHC ;  Mouse.  
[IF=2.24] Tian, Yanyan, et al. "Effects of vitamin D on renal fibrosis in diabetic nephropathy model rats." International Journal of Clinical and Experimental Pathology 7.6 (2014): 3028-3037.  IHC-P ;  Rat.  
[IF=1.922] Chi et al. Transdermal estrogen gel and oral aspirin combination therapy improves fertility prognosis via the promotion of endometrial receptivity in moderate to severe intrauterine adhesion. (2018) Mol.Med.Rep. 17:6337-6344  IHC ;  Human.  
[IF=1.922] Zhang et al. Apelin-13 protects against myocardial?infarction-induced myocardial fibrosis. (2016) Mol.Med.Rep. 13:5262-8  IHC-P/WB ;  Rat.  
[IF=1.74] Al-hamilly, Nadia Saeed, et al. "Biological roles of KGF, CTGF and TGF-β in cyclosporine-A-and phenytoin-induced gingival overgrowth: A comparative experimental animal study." Archives of oral biology 66 (2016): 38-43.  IHC-P ;  Rat.  
[IF=1.405] Han et al. MicroRNA-145 Inhibits Cell Migration and Invasion and Regulates Epithelial-Mesenchymal Transition (EMT) by Targeting Connective Tissue Growth Factor (CTGF) in Esophageal Squamous Cell Carcinoma. (2016) Med.Sci.Moni. 22:3925-3934  IHC-P ;  Human.  
[IF=1.069] He, Hongying, et al. "Carbamylated erythropoietin ameliorates cardiomyopathy via ERK (44/42) activation in rats with diabetic cardiomyopathy." Int J Clin Exp Med 10.10 (2017): 14213-14222.  IHC-P ;  Rat.  
研究領(lǐng)域 心血管  免疫學(xué)  生長(zhǎng)因子和激素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,Rat (predicted: Rabbit,Pig,Chicken,Dog)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 36 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞外基質(zhì) 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CTGF: 221-349/349 
亞    型
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009].

Function:
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.

Subunit:
Monomer.

Subcellular Location:
Secreted, extracellular space, extracellular matrix. Secreted.

Tissue Specificity:
Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.

Similarity:
Belongs to the CCN family.
Contains 1 CTCK (C-terminal cystine knot-like) domain.
Contains 1 IGFBP N-terminal domain.
Contains 1 TSP type-1 domain.
Contains 1 VWFC domain.

SWISS:
P29279

Gene ID:
1490

Database links:

Entrez Gene: 1490 Human

Entrez Gene: 64032 Rat

Omim: 121009 Human

SwissProt: P29279 Human

SwissProt: P29268 Mouse

SwissProt: Q9R1E9 Rat

Unigene: 410037 Human

Unigene: 390287 Mouse



生長(zhǎng)因子和激素( Growth Factor and Hormones)
結(jié)締組織生長(zhǎng)因子(CTGF)是調(diào)節(jié)細(xì)胞增生、分化和細(xì)胞外基質(zhì)形成的重要效應(yīng)分子,可調(diào)節(jié)機(jī)體有關(guān)組織、細(xì)胞生長(zhǎng)并與纖維化發(fā)生密切相關(guān)的一種因子,因而在肌體的各類創(chuàng)傷修復(fù)過程中具有重要的生理學(xué)意義。
產(chǎn)品圖片
Sample: Lane 1: Mouse Kidney tissue lysates Lane 2: Rat Kidney tissue lysates Primary: Anti-CTGF (bs-0743R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 36 kDa Observed band size: 38 kDa
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