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Rabbit Anti-Adiponectin Receptor 1  antibody (bs-0610R)  
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產(chǎn)品編號(hào) bs-0610R
英文名稱 Rabbit Anti-Adiponectin Receptor 1  antibody
中文名稱 脂聯(lián)素受體1抗體
別    名 ACDCR1; ADIPO R1; Adiponectin receptor protein 1; ADIPOR 1; ADIPOR1; CGI-45; CGI-45 protein; FLJ25385; PAQR1; Progestin and adipoQ receptor family member I; TESBP1A; ADR1_HUMAN.  
Specific References  (14)     |     bs-0610R has been referenced in 14 publications.
[IF=11.09] Wang, Yajing, et al. "GRK2-Mediated Desensitization of AdipoR1 in Failing Heart." Circulation (2015): CIRCULATIONAHA-114.  IP ;  Mouse.  
[IF=6.43] Morad, Vivian, Annelie Abrahamsson, and Charlotta Dabrosin. "Estradiol affects extracellular leptin: adiponectin ratio in human breast tissue in vivo." The Journal of Clinical Endocrinology & Metabolism (2014).  IHC-P ;  Human.  
[IF=6.304] Jia Gao. et al. Nicotine aggravates vascular adiponectin resistance via ubiquitin-mediated adiponectin receptor degradation in diabetic Apolipoprotein E knockout mouse. Cell Death Dis. 2021 May;12(6):1-12  WB,IF ;  Human.  
[IF=5.74] Liu, Gai-Zhen, et al. "High glucose/High Lipids impair vascular adiponectin function via inhibition of caveolin-1/AdipoR1 signalsome formation." Free Radical Biology and Medicine (2015).  WB ;  Human.  
[IF=5.14] Wu, Ming-Hsiu, et al. "Obesity Exacerbates Rat Cerebral Ischemic Injury through Enhancing Ischemic Adiponectin-Containing Neuronal Apoptosis."Molecular Neurobiology (2015): 1-12.  WB ;  Rat.  
[IF=5.037] Annamária Schaffer. et al. The ontogenies of endometrial and myometrial leptin and adiponectin receptors in pregnant rats: Their putative impact on uterine contractility. Life Sci. 2022 May;297:120465  WB ;  Rat.  
[IF=4.75] Guo et al. Effect of telmisartan on the expression of adiponectin receptors and nicotinamide adenine dinucleotide phosphate oxidase in the heart and aorta in type 2 diabetic rats. (2012) Cardiovasc.Diabetol. 11:94  IHC ;  Rat.  
[IF=3.776] Guoying Zhu. et al. Celecoxib-mediated attenuation of non-alcoholic steatohepatitis is potentially relevant to redistributing the expression of adiponectin receptors in rats. HELIYON. 2022 Jul;8:e09872  WB ;  Rat.  
[IF=2.952] Ruiying Liu. et al. Adiponectin inhibits D?gal?induced cardiomyocyte senescence via AdipoR1/APPL1. Mol Med Rep. 2021 Oct;24(4):1-10  WB ;  Mouse.  
[IF=2.59] Liu, Su, et al. "The ameliorating effect of rosiglitazone on experimental nonalcoholic steatohepatitis is associated with regulating adiponectin receptor expression in rats." European journal of pharmacology 650.1 (2011): 384.  WB ;  Rat.  
[IF=2.51] Ji, Hongfei, et al. "The effect of resveratrol on the expression of AdipoR1 in kidneys of diabetic nephropathy." Molecular Biology Reports: 1-9.  IHC-P ;  Rat.  
[IF=2.23] Cao, Zhongzan, et al. "Molecular cloning and expression analysis of adiponectin and its receptors (AdipoR1 and AdipoR2) in the hypothalamus of the Huoyan goose during different stages of the egg-laying cycle."Reproductive Biology and Endocrinology 13.1 (2015): 87.  WB ;  
[IF=1.92] Guo, Zhixin, et al. "Effect of exenatide on the cardiac expression of adiponectin receptor 1 and NADPH oxidase subunits and heart function in streptozotocin-induced diabetic rats." Diabetology & Metabolic Syndrome 6.1 (2014): 29.  IHC-P ;  Rat.  
[IF=1.28] Li, Jiehua, Shiyue Su, and Xiaona Zong. "Analysis of the association between adiponectin, adiponectin receptor 1 and diabetic cardiomyopathy."Experimental and therapeutic medicine 7.4 (2014): 1023-1027.  IHC-P ;  Rat.  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  生長因子和激素  糖尿病  內(nèi)分泌病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse,Rat (predicted: Rabbit,Chicken,Dog)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 42 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Adiponectin Receptor 1: 241-270/375 <Cytoplasmic>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Acrp30 is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine. Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance and type 2 diabetes. Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice. Conversely, adiponectin-deficient mice exhibit insulin resistance and diabetes. This insulin-sensitizing effect of adiponectin seems to be mediated by an increase in fatty-acid oxidation through activation of AMP kinase and PPAR- . Cloning of complementary DNAs encoding adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) have shown that AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver.

Function:
Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin.

Subunit:
May form homo and heteromultimers.

Subcellular Location:
Membrane; Multi-pass membrane protein. Note=Localized to the cell membrane and intracellular organelles.

Tissue Specificity:
Widely expressed. Highly expressed in skeletal muscle. Expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine.

Similarity:
Belongs to the ADIPOR family.

SWISS:
Q96A54

Gene ID:
51094

Database links:

Entrez Gene: 51094 Human

Entrez Gene: 72674 Mouse

Entrez Gene: 289036 Rat

Omim: 607945 Human

SwissProt: Q96A54 Human

SwissProt: Q91VH1 Mouse

Unigene: 5298 Human

Unigene: 259976 Mouse



脂聯(lián)素與受體結(jié)合后具有增強(qiáng)胰島素敏感性,抗高血糖,抗動(dòng)脈粥樣硬化等生物學(xué)效應(yīng),任何增加或減少脂聯(lián)素及其受體表達(dá)的方法都影響這些疾病的發(fā)生和發(fā)展.
脂聯(lián)素受體-1(AdipoR1和AdipoR2)同屬于PAQR家族,具有七次跨膜蛋白的特有結(jié)構(gòu),
mol wt:41kDa
產(chǎn)品圖片
Sample: Muscle(Mouse) Lysate at 40 ug Primary: Anti- Adiponectin Receptor 1 (bs-0610R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 42 kD Observed band size: 42 kD
Sample: Lane 1: Mouse Muscle tissue lysates Lane 2: Mouse Breast tissue lysates Lane 3: Mouse Heart tissue lysates Lane 4: Rat Muscle tissue lysates Lane 5: Rat Heart tissue lysates Primary: Anti-Adiponectin Receptor 1 (bs-0610R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 42 kDa Observed band size: 42 kDa
Tissue/cell: rat pancreas tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37∩ for 20 min; Incubation: Anti-Adiponectin Receptor 1 Polyclonal Antibody, Unconjugated(bs-0610R) 1:300, overnight at 4∑C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Tissue/cell: human rectal tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37∩ for 20 min; Incubation: Anti-Adiponectin Receptor 1 Polyclonal Antibody, Unconjugated(bs-0610R) 1:300, overnight at 4∑C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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