| 產(chǎn)品編號(hào) | bsm-61783R |
| 英文名稱 | SMARCA5 Recombinant Rabbit mAb |
| 中文名稱 | SMARCA5重組兔單抗 |
| 別 名 | hISWI; hSNF2H; ISWI; MommeD4; SMARCA5; Snf2h; WCRF135. |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 交叉反應(yīng) | Human,Mouse,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:1000-1:2000,ICC/IF=1:50-1:200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 122 kDa |
| 檢測(cè)分子量 | 122 |
| 性 狀 | Liquid |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SNF2H |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. SWISS: O60264 Gene ID: 8467 解旋酶具有內(nèi)在的ATP依賴性核小體重構(gòu)活性。含有SmarC5的配合物能夠在染色質(zhì)上形成有序的核小體陣列，這可能需要完整的組蛋白H4尾部。參與在S期復(fù)制周著絲粒異染色質(zhì)，特別是與BAZ1A結(jié)合。可能通過向rDNA啟動(dòng)子招募SIN3/HDAC1復(fù)合物來抑制rDNA位點(diǎn)的polI依賴性轉(zhuǎn)錄。也是WICH復(fù)合體的重要組成部分，是一種染色質(zhì)重塑復(fù)合體，它激活核小體并將不規(guī)則染色質(zhì)重新配置為規(guī)則的核小體陣列結(jié)構(gòu)。 |
| 產(chǎn)品圖片 |
Western blot analysis of MCF7 cell lysate. Using SMARCA5 (bsm-61783R) monoclonal antibody at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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