| 產(chǎn)品編號(hào) | bsm-61402R |
| 英文名稱 | ASPP2 Recombinant Rabbit mAb |
| 中文名稱 | P53凋亡刺激蛋白2重組兔單抗 |
| 別 名 | 53BP2; ASPP2; p53BP2; PPP1R13A; Tp53bp2. |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | WB=1:1000-1:2000,IHC-P=1:100-1:200,IHC-F=1:100-1:200,IF=1:50-1:200,ICC/IF=1:50-1:200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 126 kDa |
| 檢測(cè)分子量 | 150 |
| 性 狀 | Liquid |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TP53BP2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. SWISS: Q13625 Gene ID: 7159 p53凋亡刺激蛋白(apoptosis stimulating protein of p53，ASPP)家族是近年來發(fā)現(xiàn)的一個(gè)新蛋白家族，它包括3個(gè)成員：ASPP1、ASPP2和iASPP。其中ASPP1和ASPP2能夠與p53蛋白結(jié)合增強(qiáng)該蛋白的促進(jìn)細(xì)胞凋亡的功能，發(fā)揮抑制腫瘤的作用；而iASPP與ASPP1和ASPP2的功能截然相反，它能夠和ASPP1或ASPP2競(jìng)爭(zhēng)性地與p53結(jié)合，抑制ASPP1或ASPP2的促進(jìn)凋亡作用，具有癌基因的功能。三者的結(jié)構(gòu)相似，但功能卻完全不同，通過研究三者的關(guān)系、促進(jìn) |
| 產(chǎn)品圖片 |
Western blot analysis of MCF7 cell lysate. Using ASPP2 (bsm-61402R) monoclonal antibody at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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